Maternal Death by COVID-19 Associated with Elevated Troponin T Levels

Autor: Johnatan Torres-Torres, Raigam Jafet Martinez-Portilla, Salvador Espino y Sosa, Juan Mario Solis-Paredes, Jose Antonio Hernández-Pacheco, Paloma Mateu-Rogell, Anette Cravioto-Sapien, Adolfo Zamora-Madrazo, Guadalupe Estrada-Gutierrez, Miguel Angel Nares-Torices, Norma Patricia Becerra-Navarro, Virginia Medina-Jimenez, Jose Rafael Villafan-Bernal, Lourdes Rojas-Zepeda, Diana Hipolita Loya-Diaz, Manuel Casillas-Barrera
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Viruses; Volume 14; Issue 2; Pages: 271
ISSN: 1999-4915
DOI: 10.3390/v14020271
Popis: Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. Objective: We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death. Methods: We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission. Results: From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500–1.000). At a cutoff point of 7 ng/mL the detection rate for severe pneumonia was 83.3% (95%CI: 0.500–0.100) at 10% false-positive rate. Conclusion: COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje