Psychological Stress and Immunological Modulations in Early-stage Melanoma Patients
| Autor: | Michael Trapp, Josef W. Egger, Hans Peter Brezinsek, Clara Curiel-Lewandrowski, Alexander Avian, Erika Richtig, Peter Michael Rohrer, Andrea Berghold, Hans Peter Kapfhammer, Ulrike Demel, Eva Maria Trapp |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Chemokine Skin Neoplasms medicine.medical_treatment Pilot Projects Dermatology CD16 CD8-Positive T-Lymphocytes CCL5 Internal medicine medicine Humans Chemokine CCL5 Melanoma Aged biology business.industry Interleukin-6 Case-control study Interleukin Cancer General Medicine Middle Aged medicine.disease CD4 Lymphocyte Count Interleukin-10 Killer Cells Natural Cytokine Case-Control Studies biology.protein Female Chemokines business Stress Psychological |
| Zdroj: | Acta dermato-venereologica. 95(6) |
| ISSN: | 1651-2057 |
| Popis: | Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients. |
| Databáze: | OpenAIRE |
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