A poly(γ-glutamic acid)–amphiphile complex as a novel nanovehicle for drug delivery system

Autor:	Haruhito Matsumoto, Hidenori Kaminishi, Katsumasa Matsunaga, Taro Kimura, Jun Ohno, Yu-shi Hirofuji, Kunihisa Taniguchi, Tetsuyuki Akao, Sumio Ohtono, Jun-ichi Nagao, Tamaki Cho, Rieko Imayoshi
Rok vydání:	2010
Předmět:	Male Chemical structure Pharmaceutical Science Nanoparticle Mice Drug Delivery Systems In vivo Amphiphile medicine Animals Doxorubicin Particle Size Sarcoma 180 Antibiotics Antineoplastic Chemistry Cationic polymerization Lipids Combinatorial chemistry Polyglutamic Acid Biochemistry Drug delivery Dispersion stability Nanoparticles Drug Screening Assays Antitumor medicine.drug
Zdroj:	Journal of Drug Targeting. 18:550-556
ISSN:	1029-2330 1061-186X
DOI:	10.3109/10611861003599453
Popis:	Recently, many studies have focused on biomedical and pharmaceutical applications of self-assembled nanoparticles. In addition, several biodegradable nanoparticles have been reported to possess poor dispersion stability and poor size-controllability. However, these nanoparticles require complicated fabrication procedures using synthesis techniques. We developed an efficient method for producing nanoparticles derived from a biological origin of molecule poly(gamma-glutamic acid) (gamma-PGA), a cationic lipid, and doxorubicin (Dox). The complex had a size of 510 nm and was able to encapsulate over 90% of the added Dox. An in vivo assay of antitumor activity demonstrated that the complex had significant antitumor activity in sarcoma 180-bearing mice, and was effectively accumulated in solid tumors based on the EPR effect. The data suggested that this complex is a promising formulation of gamma-PGA for targeted delivery to solid tumors. gamma-PGA-12GP2 complexes may possess several unique advantages, including simplicity of nanoparticle preparation, high drug-carrying capacity, appropriate size to allow deeper penetration based on EPR effect into solid tumors, and lack of necessity to modify the chemical structure of the drugs. These data indicate that the gamma-PGA-12GP2 complexes are potentially useful in cancer chemotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcf8b7d57dfb399cb85b20324d6a8c8 https://doi.org/10.3109/10611861003599453 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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