Fast‐spin‐echo versus rapid gradient‐echo for 3D magnetization‐prepared acquisitions: Application to inhomogeneous magnetization transfer

Autor: Manuel Taso, Fanny Munsch, Olivier M. Girard, Guillaume Duhamel, David C. Alsop, Gopal Varma
Přispěvatelé: Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2022
Předmět:
Zdroj: Magnetic Resonance in Medicine
Magnetic Resonance in Medicine, 2022, ⟨10.1002/mrm.29461⟩
ISSN: 1522-2594
0740-3194
Popis: International audience; To evaluate the benefits of Fast Spin Echo (FSE) imaging over Rapid Gradient-Echo (RAGE) for Magnetization-prepared inhomogeneous Magnetization Transfer (ihMT) imaging. Methods: A 3D FSE sequence was modified to include an ihMT preparation (ihMT-FSE) with an optional CSF suppression based on an Inversion-Recovery (ihMT-FLAIR). After numerical simulations assessing SNR benefits of FSE and the potential impact of an additional inversion-recovery, ihMT-RAGE, ihMT-FSE and ihMT-FLAIR sequences were compared in a group of 6 healthy volunteers, evaluating image quality, thermal and physiological noise as well as quantification using an ihMTsat approach. A preliminary exploration in the cervical spinal cord was also conducted in a group of 3 healthy volunteers. Results: Several fold improvement in thermal SNR was observed with ihMT-FSE in agreement with numerical simulations. However, we observed significantly higher physiological noise in ihMT-FSE compared to ihMT-RAGE that was mitigated in ihMT-FLAIR, which provided the best total SNR (+74% and 49% compared to ihMT-RAGE in the white and gray matter, p0.004). IhMTsat quantification was successful in all cases with strong correlation between all sequences (r 2 >0.75). Early experiments showed potential for spinal cord imaging. Conclusions: FSE generally offers higher SNR compared to gradient-echo based acquisitions for magnetization-prepared contrasts as illustrated here in the case of ihMT. However, physiological noise has a significant effect, but an IR-based CSF suppression was shown to be efficient in mitigating effects of CSF motion.
Databáze: OpenAIRE
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