The platelet angiotensin II receptor in type I diabetes: studies in patients with and without nephropathy
| Autor: | Lesley V. Campbell, Monika A. Pawlak, V. Timmermans, John A. Charlesworth, MM Makarious, K. A. Duggan, Graham J. Macdonald |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Angiotensin receptor Time Factors Receptor expression Clinical Biochemistry Biochemistry Nephropathy Diabetic nephropathy Internal medicine Diabetes mellitus medicine Humans Diabetic Nephropathies Receptor Angiotensin II receptor type 1 Receptors Angiotensin business.industry General Medicine medicine.disease Angiotensin II Endocrinology Diabetes Mellitus Type 1 Female business |
| Zdroj: | European journal of clinical investigation. 23(9) |
| ISSN: | 0014-2972 |
| Popis: | Experimental studies demonstrate impaired regulation of the mesangial angiotensin I1 (AII) recep- tor in diabetes. This could contribute to the distur- bance of glomerular blood flow and the development of diabetic nephropathy. The aim of this study was to determine whether a similar receptor abnormality occurs in patients with type I insulin-dependent dia- betes mellitus (IDDM) and if so whether this is more prevalent in patients with micro- or macro-albumi- nuria. The platelet A11 receptor was chosen because of its availability from the circulation and its comparable regulatory properties to tissue-based receptors. The interaction between plasma All and its platelet recep- tor was examined in 45 patients with TDDM and 36 age- and sex-matched control subjects. Seven patients had clinical nephropathy and two had persistent micro-albuminuria. The duration of diabetes varied from 1 month to 42 years. There was a significant inverse correlation between plasma AIT and the logarithm of receptor number in the control group (r= -0.555, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text