Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates
| Autor: | Erinn M. Grigsby, Angel V. Peterchev, Tobias Egner, Zhi-De Deng, Hrishikesh M. Rao, Michael L. Platt, Vincent Prevosto, Frank W. Petraglia, Jerel K. Mueller, Warren M. Grill, Marc A. Sommer |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Patch-Clamp Techniques genetic structures Computer science medicine.medical_treatment Action Potentials Prefrontal Cortex Stimulation Article 03 medical and health sciences 0302 clinical medicine medicine Recording electrode Animals Prefrontal cortex Electrodes Stimulus strength 030304 developmental biology Neurons 0303 health sciences Artifact (error) General Neuroscience Nervous tissue Equipment Design Macaca mulatta Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Female Neuron Artifacts Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report novel methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in intact, awake monkeys (Macaca mulatta). We recorded action potentials within ~1 ms after 0.4 ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared to sham stimulation. The methodology is compatible with standard equipment in primate laboratories, allowing for easy implementation. Application of these new tools will facilitate the refinement of next generation TMS devices, experiments, and treatment protocols. |
| Databáze: | OpenAIRE |
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