Two distinct immunopathological profiles in autopsy lungs of COVID-19
| Autor: | Tobias Junt, Gieri Cathomas, Kirsten D. Mertz, Viktor H. Koelzer, Holger Moch, Francesca Demichelis, Thomas Hoyler, Alexandar Tzankov, Nathalie Schwab, Niels Willi, Maurice Henkel, Werner Kempf, Angela Frank, Ronny Nienhold, Thomas Menter, Markus Tolnay, Veronika Zsikla, Mattia Barbareschi, Jasmin D. Haslbauer, Yari Ciani |
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| Přispěvatelé: | University of Zurich, Mertz, Kirsten D |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology General Physics and Astronomy Autopsy CD8-Positive T-Lymphocytes medicine.disease_cause Transcriptome 0302 clinical medicine Interferon Sequencing lcsh:Science Lung Coronavirus Aged 80 and over Multidisciplinary Respiratory disease virus diseases Middle Aged Viral Load respiratory system 3100 General Physics and Astronomy Vaccination 030220 oncology & carcinogenesis Cytokines Female Infection Coronavirus Infections Viral load medicine.drug medicine.medical_specialty Immunopathogenesis Coronavirus disease 2019 (COVID-19) Science Pneumonia Viral 610 Medicine & health 1600 General Chemistry Biology Article General Biochemistry Genetics and Molecular Biology Betacoronavirus 03 medical and health sciences Immune system 1300 General Biochemistry Genetics and Molecular Biology 10049 Institute of Pathology and Molecular Pathology medicine Humans Pandemics Gene Aged SARS-CoV-2 business.industry Gene Expression Profiling Macrophages COVID-19 General Chemistry medicine.disease respiratory tract diseases Pneumonia 030104 developmental biology Viral infection Normal lung Immunology lcsh:Q Interferons business CD8 |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-18854-2 |
| Popis: | Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) and normal lung tissues (n = 9 tissues from 6 patients). Two distinct immunopathological reaction patterns of lethal COVID-19 are identified. One pattern shows high local expression of interferon stimulated genes (ISGhigh) and cytokines, high viral loads and limited pulmonary damage, the other pattern shows severely damaged lungs, low ISGs (ISGlow), low viral loads and abundant infiltrating activated CD8+ T cells and macrophages. ISGhigh patients die significantly earlier after hospitalization than ISGlow patients. Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment. The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progression |
| Databáze: | OpenAIRE |
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