Occurrence and de novo biosynthesis of follicle stimulating hormone (FSH) in benign and malignant conditions of human breast
| Autor: | Chandra J. Panchal, Rachel Joseph, Roshan F. Chinoy, Nandini A. Sheth, Anil R. Sheth, Garde Sv |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cytoplasm
endocrine system Cancer Research medicine.medical_specialty Stromal cell Radioimmunoassay Breast Neoplasms Biology medicine.disease_cause Epithelium Malignant transformation Immunoenzyme Techniques Breast Diseases Follicle-stimulating hormone Breast cancer Internal medicine medicine Humans Breast Fibrocystic Breast Disease skin and connective tissue diseases Milk Human Immunoperoxidase medicine.disease Endocrinology Oncology Fibroadenoma Follicle Stimulating Hormone Breast carcinoma Carcinogenesis Carcinoma in Situ hormones hormone substitutes and hormone antagonists Immunostaining |
| Zdroj: | Cancer Letters. 75:1-9 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(93)90200-s |
| Popis: | We report the occurrence as well as biosynthesis of a pituitary hormone, follicle stimulating hormone (FSH) in human breast. Using immunoperoxidase localization technique, both FSH and beta-FSH were localized in cytoplasm of epithelial cells but not in stromal cells. Immunostaining was more intense in benign and malignant specimens as compared to normal. In vitro radiolabelled precursor experiments with breast tissue explants indicate de novo synthesis of FSH. Human milk had higher concentrations of FSH as compared to serum. In gonads, FSH is involved in the cellular growth, differentiation and function. The presence of higher levels of FSH in benign mammary tumors and breast cancer when compared to normal breast supports the suggestion that FSH might have a role in the process of breast malignant transformation. |
| Databáze: | OpenAIRE |
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