Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer
| Autor: | Holger Moch, Lukas Bubendorf, Tobias Eichenberger, Hansjörg Rüfenacht, Guido Sauter, Thomas C. Gasser, Tobias Zellweger, Alexander Bachmann, Gianfranco Mattarelli, Inti Zlobec, Michael J. Mihatsch, Sarah Günther, Spasenija Savic, Enrico Curschellas |
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| Přispěvatelé: | University of Zurich, Bubendorf, L |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Biochemical recurrence Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Urology 610 Medicine & health urologic and male genital diseases Risk Assessment Immunoenzyme Techniques Prostate cancer Risk Factors Prostate 10049 Institute of Pathology and Molecular Pathology Preoperative Care Biopsy Biomarkers Tumor medicine Humans Neoplasm Invasiveness 1306 Cancer Research Prospective Studies Stage (cooking) Aged Neoplasm Staging Prostatectomy medicine.diagnostic_test business.industry Biopsy Needle Hazard ratio Prostatic Neoplasms Cancer Middle Aged Prognosis medicine.disease Ki-67 Antigen medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Oncology 2730 Oncology Neoplasm Recurrence Local Tumor Suppressor Protein p53 business |
| Popis: | Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinical stage T1c and 23% with T2) who subsequently underwent radical prostatectomy was prospectively analysed for Gleason score, number and percentage of positive cores (NPC, PPC), total percentage of biopsy tissue with tumour (TPT), maximum tumour percentage per core (MTP), and expression of Ki67, Bcl-2 and p53. All biopsy features were significantly associated with at least one feature of the radical prostatectomy specimen. pT stage was independently predicted by PSA, seminal vesicle invasion by Ki67 LI, positive margins by PSA and MTP, large tumour diameter by PSA and PPC, and Gleason score by biopsy Gleason score, MTP, and Ki67 LI, respectively. Biopsy Gleason score, NPC (1 vs. >1), TPT ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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