Dynamic Contrast-Enhanced Magnetic Resonance Imaging in the Assessment of Inflammatory Breast Cancer Prior to and After Neoadjuvant Treatment
| Autor: | C.F.J.M. Blanken-Peeters, J. Hans W. de Wilt, Dominique J. P. van Uden, Ritse M. Mann, Carla Meeuwis |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Inflammatory breast cancer 030218 nuclear medicine & medical imaging 03 medical and health sciences Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine Neoadjuvant treatment Medicine skin and connective tissue diseases Complete response medicine.diagnostic_test Tumor size business.industry Skin thickening Magnetic resonance imaging medicine.disease Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Dynamic contrast Oncology 030220 oncology & carcinogenesis Original Article Surgery business Post-chemotherapy Nuclear medicine |
| Zdroj: | Breast Care. Multidisciplinary journal for research, diagnosis and therapy, 12, 224-229 Breast Care. Multidisciplinary journal for research, diagnosis and therapy, 12, 4, pp. 224-229 |
| ISSN: | 1661-3791 |
| Popis: | Background: The aim of this study was to describe the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features of inflammatory breast cancer (IBC) and to assess the value of DCE-MRI for the prediction of pathological complete response (pCR). Methods: Image analysis was performed in 15 patients with IBC (cT4d) and 12 patients with non-IBC (cT2), and included the assessment of BIRADS characteristics, skin alterations, enhancement characteristics, and changes post chemotherapy. Sensitivity and specificity of DCE-MRI for the presence of residual disease were obtained. Pearson's correlation coefficients were calculated comparing the (preoperative) tumor size with the histological size. Results: Skin thickening/enhancement (80%) and non-mass-like enhancement (66.7%) occurred more often in IBC (16.7 vs. 8.3% in non-IBC). In 2 of 3 cases of IBC, pCR was correctly predicted (sensitivity 92%, specificity 67%), compared to 3 of 5 cases in non-IBC (sensitivity 86%, specificity 40%). Lower peak enhancement might be associated with a higher likelihood of pCR in IBC. No other parameters predicted eventual pCR. In IBC, no correlation between preoperative tumor size and histological size was found (r = 0.22, p = 0.50), whereas in non-IBC, size estimations were more accurate (r = 0.75, p = 0.03). Conclusion: IBC is characterized on MRI by skin changes and non-mass-like enhancement. Radiological complete response seems indicative of pCR in IBC and non-IBC. Size estimation of residual disease in IBC appears to be inaccurate. |
| Databáze: | OpenAIRE |
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