Broccoli and human health: immunomodulatory effect of sulforaphane in a model of colon cancer
| Autor: | Meir Djaldetti, Hanna Bessler |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell Survival Colorectal cancer medicine.medical_treatment Anti-Inflammatory Agents Brassica Peripheral blood mononuclear cell 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Isothiocyanates Cell Line Tumor medicine Anticarcinogenic Agents Humans Secretion Cell Proliferation Glucoraphanin medicine.disease 030104 developmental biology Cytokine chemistry Sulfoxides 030220 oncology & carcinogenesis Colonic Neoplasms Leukocytes Mononuclear Cancer research Cytokines Tumor necrosis factor alpha HT29 Cells Food Science Sulforaphane |
| Zdroj: | International Journal of Food Sciences and Nutrition. 69:946-953 |
| ISSN: | 1465-3478 0963-7486 |
| DOI: | 10.1080/09637486.2018.1439901 |
| Popis: | The favourable properties of broccoli on human health are due to their abundant content of vitamins, minerals and isothiocyanates, the sulforaphane (SFN) being the most important. SFN is created from its precursor glucoraphanin and it is released by myrosinase enzymes produced during crushing of the plant. SFN has been shown to possess anti-inflammatory and anticancer properties. The aim of the study was to determine if SFN may affect the immune dialogue between human peripheral blood mononuclear cells (PBMCs) and HT-29 and RKO human colon cancer cells lines. Non- or mitogen-stimulated PBMCs were incubated with various concentrations of SFN, and the secretion of TNFα, IL-1β, IL-6, IFNγ, IL-2, IL-10 and IL-1ra was determined. In addition, the effect of SFN on the production of these cytokines by PBMCs co-cultured with colon carcinoma cells was examined. SFN exerted a concentration-dependent inhibitory effect on the inflammatory cytokine production by the immune cells. The impact of SFN on the interaction between immune and colon cancer cells underscores its capacity for cancer prevention and development. |
| Databáze: | OpenAIRE |
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