Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension
| Autor: | Uri Ladabaum, Michelle L. Woods, William L. Hasler, Sherin S. Koshy, Forrest G. Hooper, Chung Owyang |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Atropine Male medicine.medical_specialty Physiology Nausea Indomethacin Pain Gastroenterology Granisetron Reference Values Physiology (medical) Internal medicine Pressure medicine Humans Antrum Hepatology Electromyography business.industry Gastric distension Stomach digestive oral and skin physiology Muscle Smooth Abdominal distension Dilatation Barostat digestive system diseases Mechanoreceptor medicine.anatomical_structure Anesthesia Antiemetics Female medicine.symptom Gastrointestinal Motility business Mechanoreceptors |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 275:G418-G424 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.1998.275.3.g418 |
| Popis: | Nausea and gastric dysrhythmias occur in conditions associated with gastric distension. The roles of distal and proximal gastric mechanoreceptors in these responses are unexplored. Because antral distension induces vomiting in animals and antral and fundic vagal afferent discharges differ, we hypothesized that distal gastric distension in humans leads to greater symptomatic and dysrhythmic responses than proximal distension. Symptoms and electrogastrograms were recorded in healthy humans during distal and proximal gastric distension with a barostat. Distal but not proximal distension induced nausea and a 747 ± 250% increase in dysrhythmic power ( P < 0.05), responses not affected by granisetron, indomethacin, or atropine, agents that block dysrhythmias in other settings. In the distal stomach, bloating and pain developed at lower pressures ( P < 0.05) not modified by granisetron, and compliance was significantly lower ( P < 0.05). In conclusion, gastric mechanoreceptor activation in the less-compliant distal stomach produces nausea and dysrhythmias via non-5-hydroxytryptamine3(5-HT3), non-prostaglandin-dependent, and noncholinergic pathways. Distal mechanoreceptor activation induces greater bloating and pain than proximal mechanoreceptor activation via 5-HT3-independent pathways. |
| Databáze: | OpenAIRE |
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