Zika Virus-Induction of the Suppressor of Cytokine Signaling 1/3 Contributes to the Modulation of Viral Replication
| Autor: | Jae Kyung Lee, Rak Kyun Seong, Ok Sarah Shin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment viruses lcsh:Medicine Biology Article suppressor of cytokine signaling Interferon medicine Immunology and Allergy zika virus SOCS3 Molecular Biology Gene knockdown Innate immune system General Immunology and Microbiology Suppressor of cytokine signaling 1 lcsh:R interferon biology.organism_classification Virology antiviral Flavivirus Infectious Diseases Cytokine Viral replication medicine.drug |
| Zdroj: | Pathogens Pathogens, Vol 9, Iss 3, p 163 (2020) Volume 9 Issue 3 |
| ISSN: | 2076-0817 |
| Popis: | Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged and caused global outbreaks since 2007. Although ZIKV proteins have been shown to suppress early anti-viral innate immune responses, little is known about the exact mechanisms. This study demonstrates that infection with either the African or Asian lineage of ZIKV leads to a modulated expression of suppressor of cytokine signaling (SOCS) genes encoding SOCS1 and SOCS3 in the following cell models: A549 human lung adenocarcinoma cells JAr human choriocarcinoma cells human neural progenitor cells. Studies of viral gene expression in response to SOCS1 or SOCS3 demonstrated that the knockdown of these SOCS proteins inhibited viral NS5 or ZIKV RNA expression, whereas overexpression resulted in an increased expression. Moreover, the overexpression of SOCS1 or SOCS3 inhibited the retinoic acid-inducible gene-I-like receptor-mediated activation of both type I and III interferon pathways. These results imply that SOCS upregulation following ZIKV infection modulates viral replication, possibly via the regulation of anti-viral innate immune responses. |
| Databáze: | OpenAIRE |
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