Astrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection
| Autor: | Laurent Kaiser, Mylène Docquier, Arnaud G L'Huillier, Lara Turin, Diem-Lan Vu, Tom J. Petty, Samuel Cordey, Francisco Brito, Klara M. Posfay-Barbe, Manuel Schibler, Evgeny M. Zdobnov |
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| Rok vydání: | 2016 |
| Předmět: |
astrovirus MLB2
0301 basic medicine Microbiology (medical) Epidemiology viruses 030106 microbiology lcsh:Medicine viral meningitis Viremia Biology Virus lcsh:Infectious and parasitic diseases Microbiology Astrovirus astrovirus 03 medical and health sciences fluids and secretions Cerebrospinal fluid ddc:590 Astroviridae Infections Prevalence medicine Viral meningitis Humans lcsh:RC109-216 Phylogeny Feces immunocompromised host ddc:616 Astrovirus MLB2 a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection viremia Research enteric infections lcsh:R High-Throughput Nucleotide Sequencing medicine.disease biology.organism_classification Meningitis Viral Virology 3. Good health 030104 developmental biology Infectious Diseases RNA Viral mamastrovirus Meningitis Switzerland |
| Zdroj: | Emerging infectious diseases Emerging Infectious Diseases, Vol. 22, No 5 (2016) pp. 846-853 Emerging Infectious Diseases Emerging Infectious Diseases, Vol 22, Iss 5, Pp 846-853 (2016) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | This virus is an unrecognized cause of central nervous system infection, particularly among immunocompromised patients. Next-generation sequencing has identified novel astroviruses for which a pathogenic role is not clearly defined. We identified astrovirus MLB2 infection in an immunocompetent case-patient and an immunocompromised patient who experienced diverse clinical manifestations, notably, meningitis and disseminated infection. The initial case-patient was identified by next-generation sequencing, which revealed astrovirus MLB2 RNA in cerebrospinal fluid, plasma, urine, and anal swab specimens. We then used specific real-time reverse transcription PCR to screen 943 fecal and 424 cerebrospinal fluid samples from hospitalized patients and identified a second case of meningitis, with positive results for the agent in the patient’s feces and plasma. This screening revealed 5 additional positive fecal samples: 1 from an infant with acute diarrhea and 4 from children who had received transplants. Our findings demonstrate that astrovirus MLB2, which is highly prevalent in feces, can disseminate outside the digestive tract and is an unrecognized cause of central nervous system infection. |
| Databáze: | OpenAIRE |
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