Endotoxin at the Maternal–Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes
| Autor: | Palmera Baltazar, Remigio M. Olveda, Jonathan D. Kurtis, Veronica Tallo, Luz P. Acosta, Jeffrey A. Bailey, Jennifer F. Friedman, Ronald C. Stuart, Hannah W Wu, Ayush Joshi, Emily A. McDonald |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Alcohol Drinking Philippines 030231 tropical medicine Gestational Age Schistosomiasis Cohort Studies Hookworm Infections 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Virology Humans Medicine Maternal-Fetal Exchange Hookworm infection Randomized Controlled Trials as Topic Fetal Growth Retardation biology business.industry Infant Newborn Gestational age Articles Fetal Blood medicine.disease biology.organism_classification Endotoxins Gastrointestinal Tract 030104 developmental biology Infectious Diseases In utero Bacterial Translocation Cord blood Immunology Cytokines Health Resources Gestation Female Parasitology Carrier Proteins business Cohort study |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 99:495-501 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Low- and middle-income countries (LMICs) carry a high burden of infectious diseases associated with impaired gut integrity, leading to microbial translocation. Pregnancies in this setting are at high risk of fetal growth restriction (FGR). We examined the association among specific risk factors for impaired gut integrity (schistosomiasis, hookworm infection, and alcohol consumption), blood endotoxin levels, and FGR. Endotoxins, lipopolysaccharide-binding proteins (LBPs), and cytokines were measured in blood from women at 32 weeks gestation, the maternal-fetal interface (MFI) at delivery, and cord blood at delivery. Resolution of schistosomiasis had no impact on endotoxin levels; however, maternal hookworm infection and alcohol consumption were associated with modest increases in endotoxin at the MFI. Cytokines responses within the maternal peripheral blood and blood from the MFI were positively associated with endotoxins, but many cord blood cytokines were negatively associated with endotoxins. Newborns with FGR also had higher levels of endotoxins at the MFI. Risk factors for microbial translocation may lead to increased levels of endotoxins at the MFI, which may contribute to poor growth in utero. |
| Databáze: | OpenAIRE |
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