Evaluation of a new rapid immunoassay for the detection of Helicobacter pylori in faeces: a prospective pilot study

Autor:	M. R. Rossi, V. Abbasciano, Sergio Gullini, Lucio Trevisani, V. Matarese, M. Ruina, S. Sartori
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Rapid immunoassay Spirillaceae Rapid urease test Gastroenterology Helicobacter Infections Immunoenzyme Techniques Feces Internal medicine medicine Humans Pharmacology (medical) Helicobacter Aged Aged 80 and over Immunoassay Antigens Bacterial Helicobacter pylori Hepatology biology medicine.diagnostic_test Stool test business.industry Middle Aged biology.organism_classification Immunology Female Reagent Kits Diagnostic Epidemiologic Methods business
Zdroj:	Alimentary Pharmacology and Therapeutics. 21:485-489
ISSN:	1365-2036 0269-2813
DOI:	10.1111/j.1365-2036.2005.02355.x
Popis:	Summary Background : Detection of Helicobacter pylori antigen in faeces is a valid method to diagnose H. pylori infection. Presently available stool tests are performed in the laboratory, and diagnostic report is delayed. Aim : To evaluate a new rapid stool test in a pre-treatment setting and to compare it with a validated laboratory stool test. Methods : A total of 105 patients underwent gastroscopy with brush cytology, and biopsies for histology and rapid urease test, to assess H. pylori presence. Helicobacter pylori-status was considered positive if at least two tests were positive; negative if all tests were negative; indeterminate if one test was positive and two negative. Stool specimens were tested using either a rapid immunoassay kit (ImmunoCard STAT) or a laboratory enzyme immunoassay kit (Hp StAR). Results : Sixty patients were infected with H. pylori, 44 non-infected, one indeterminate. The sensitivity and specificity of ImmunoCard STAT were 85 and 93%; those of Hp StAR were 88 and 100% (not significant). Conclusions : ImmunoCard STAT seems a reliable method for detecting H. pylori in untreated patients. It could replace laboratory stool tests, as it is easy and can be performed quickly. These characteristics might be a breakthrough for diagnosing H. pylori in the doctor's office.
Databáze:	OpenAIRE
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