Co-occurrence of EBV-positive classic Hodgkin lymphoma and B-cell lymphomas of different clonal origins: A case report and literature review
| Autor: | Kennosuke Karube, Takeaki Tomoyose, Iwao Nakazato, Kei Kohno, Mitsuyoshi Takatori, Kazuiku Ohshiro |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human Lymphoproliferative disorders Biology medicine.disease_cause Virus Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Humans B cell General Medicine Gene rearrangement medicine.disease Epstein–Barr virus Hodgkin Disease Lymphoproliferative Disorders Lymphoma 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunoglobulin heavy chain Lymphoma Large B-Cell Diffuse Neoplasm Recurrence Local Diffuse large B-cell lymphoma |
| Zdroj: | Pathology internationalREFERENCES. 70(11) |
| ISSN: | 1440-1827 |
| Popis: | Although cases with metachronous or synchronous co-occurrence of classic Hodgkin lymphoma (CHL) and B-cell non-Hodgkin lymphoma (B-NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein-Barr virus (EBV)-positive settings. Here, we report a case of a 38-year-old male with CHL, followed by the recurrence of EBV-positive mucocutaneous ulcers of the large intestine and EBV-positive diffuse large B-cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co-occurrence of CHL and B-NHL in EBV-positive settings. In contrast to EBV-negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B-cells could simultaneously proliferate in EBV-associated settings, providing a new insight into the pathogenesis of EBV-associated lymphoproliferative disorders. |
| Databáze: | OpenAIRE |
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