Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?
| Autor: | Cheryl L. Sisk, Kristen M. Culbert, Kelly L. Klump, Laura A. Mayhall, Alexandra S. Burt, Natasha Fowler |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
050103 clinical psychology
Adolescent medicine.drug_class Physiology Models Psychological Article 03 medical and health sciences 0302 clinical medicine Prepuberty medicine Humans 0501 psychology and cognitive sciences Genetic Predisposition to Disease Bulimia Child Biological Psychiatry Binge eating Estradiol 05 social sciences Puberty Moderation Twin study Clinical Psychology Psychiatry and Mental health Estrogen Normative Female medicine.symptom Psychology Body mass index 030217 neurology & neurosurgery Hormone |
| Zdroj: | Journal of abnormal psychology. 127(5) |
| ISSN: | 1939-1846 |
| Popis: | Puberty is a critical period for changes in genetic effects for binge eating in girls. Previous twin studies show increases in genetic influences on binge eating from prepuberty (∼0%) to midpuberty and beyond (∼50%). However, little is known about the factors that drive these shifts in genetic effects. A small pilot study showed that pubertal activation of estrogen may contribute to increases in genetic influences, possibly via hormonally induced changes in gene expression. However, large-scale studies investigating hormone effects on genetic risk are lacking. Thus, the purpose of the present study was to examine the effects of estrogen on genetic influences for binge eating in 964 female twins (ages 8-16 years) from the Michigan State University Twin Registry. Binge eating was assessed with the Minnesota Eating Behaviors Survey, whereas afternoon saliva samples were assayed for estradiol levels using standard enzyme immunoassays. Twin moderation models showed substantial differences in genetic influences on binge eating across estradiol levels. Stronger genetic effects were observed at lower (rather than higher) estradiol levels, even when controlling for the effects of age, body mass index, the physical changes of puberty, and the onset of menses. Overall, findings suggest that comparatively lower levels of estradiol during this critical period may disrupt normative developmental processes and enhance genetic influences on binge eating. (PsycINFO Database Record |
| Databáze: | OpenAIRE |
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