Association between different morphological types and abnormal karyotypes in early pregnancy loss
| Autor: | Carlo Carcassi, R Murru, Gian Benedetto Melis, Marco Angiolucci, Valerio Mais |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Early Pregnancy Loss Gestational sac Aneuploidy Chromosome Disorders Trisomy 22 Ultrasonography Prenatal Pregnancy medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Yolk sac Yolk Sac Chromosome Aberrations Gynecology Fetus Radiological and Ultrasound Technology Obstetrics business.industry Obstetrics and Gynecology Karyotype Organ Size General Medicine medicine.disease Abortion Spontaneous Pregnancy Complications Pregnancy Trimester First medicine.anatomical_structure Italy Reproductive Medicine Products of conception embryonic structures Female business Maternal Age Microsatellite Repeats |
| Zdroj: | Ultrasound in Obstetrics & Gynecology. 37:219-225 |
| ISSN: | 0960-7692 |
| Popis: | Objectives To identify the abnormal transvaginal ultrasound (TVS) findings typical of aneuploidic pregnancies that end with early pregnancy loss (EPL). Methods This was a prospective clinical trial over a 2½-year period from January 2004 to June 2006 at the University Hospital of Cagliari, Italy. One hundred and fifty-six singleton pregnancies with EPL were evaluated by TVS, both before and at the moment of EPL diagnosis. Fetal karyotyping was performed on products of conception using microsatellite analysis to exclude maternal contamination in 46,XX cases. The proportions of abnormal karyotypes were compared among different groups of EPLs characterized by different morphological features. Results Six morphological types were identified in EPLs, one normal and five abnormal (small gestational sac, small embryo/fetus, early symmetrical arrested growth, enlarged yolk sac and empty sac). The highest rate of chromosomal abnormalities was observed in the early symmetrical arrested growth group (100%), followed by small embryo/fetus (94.1%), enlarged yolk sac (93.3%) and empty sac (72.2%) groups. The majority of cases of trisomy 22 (92.3%) were in the enlarged yolk sac group and the majority of cases with a 45,X karyotype were in the small embryo/fetus group (77.8%). Conclusions There is an association in EPLs between some abnormal karyotypes and some morphological types. The demonstration by TVS of abnormalities in the development of early pregnancy structures could be helpful for predicting aneuploidy in EPLs. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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