Platelet Function in Preleukaemia
| Autor: | Eero Ikkala, R. Lintula, G.H. Borgström, Pekka Vuopio, V. Rasi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Platelet Aggregation Platelet Function Tests Preleukemia Biology Platelet Factor 3 03 medical and health sciences Platelet Adhesiveness 0302 clinical medicine Myeloproliferative Disorders Bone Marrow Platelet adhesiveness Internal medicine medicine Humans Platelet Chromosomes Human 4-5 Mean platelet volume Aged 030304 developmental biology Chromosome Aberrations 0303 health sciences Thrombocytosis Platelet Count Hematology Middle Aged medicine.disease Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female Bone marrow |
| Zdroj: | Scandinavian Journal of Haematology. 26:65-71 |
| ISSN: | 0036-553X |
| Popis: | Platelet function was studied in 17 patients with preleukaemia and the results were compared with those of 28 patients with other chronic myeloproliferative disorders. The test pattern included bleeding time (Ivy), platelet retention (Hellem II), PF-3 activity and availability after exposure to ADP and kaolin, and ADP-, epinephrine-, collagen- and ristocetin-induced aggregations. Platelet function was frequently impaired in patients with preleukemia. The defects were similar to those found in other myeloproliferative disorders. The most consistent finding was defective aggregation. Patients with thrombocytosis and/or with increased amounts of megakaryocytes in the bone marrow had fewer defects in platelet function. Retention defect was more common in patients with hypolobulated megakaryocytes, especially in those having a specific marker, the 5q- chromosome, in their bone marrow cells. |
| Databáze: | OpenAIRE |
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