Heat shock protein 27 (HSP27/HSPB1) expression is increased in patients with primary and secondary myelofibrosis and may be affecting their survival
| Autor: | Katarina Marija Tupek, Tajana Štoos-Veić, Vlatko Pejša, Ana Livun, Iva Gecek, Gorana Aralica, Marko Lucijanic, Rajko Kusec |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cancer Research animal structures Philadelphia Chromosome Negative HSP27 Heat-Shock Proteins 03 medical and health sciences 0302 clinical medicine Hsp27 hemic and lymphatic diseases Secondary Myelofibrosis Heat shock protein medicine Biomarkers Tumor Humans In patient Myelofibrosis Heat-Shock Proteins Aged biology business.industry Neoplastic disease Hematopoietic stem cell Hematology HSP27 myelofibrosis survival Middle Aged medicine.disease Prognosis Survival Rate 030104 developmental biology medicine.anatomical_structure Oncology Primary Myelofibrosis 030220 oncology & carcinogenesis Immunology Cancer research biology.protein Female business Follow-Up Studies Molecular Chaperones |
| Popis: | Primary myelofibrosis (PMF) is a neoplastic disease originating from clonally transformed pluripotent hematopoietic stem cell. Heat shock proteins (HSP) are expressed by cells in response to different stress stimuli, thus allowing cells to survive in otherwise lethal conditions. Heat shock protein 27 (HSP27) is a small HSP transcribed from heat shock protein family B member 1 (HSPB1) gene. Increased HSP27 expression and phosphorylation were observed in a large number of neoplastic diseases and they have mostly been associated with more aggressive disease features, metastatic behavior, resistance to chemotherapy and poor prognosis. However, these findings are not universal for different malignant diseases and higher HSP27 expression was recognized as a positive marker in some situations. Increased HSP27 expression was also shown to be atheroprotective. In this study, we show the genetic upregulation of HSPB1/HSP27 in myelofibrosis and its potentially favorable impact on survival. |
| Databáze: | OpenAIRE |
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