Spinal Surgery after Bilateral Subthalamic Stimulation for Patients with Parkinson’s Disease: A Retrospective Outcome Analysis of Pain and Functional Control
| Autor: | Isao Date, Kyohei Kin, Yasuyuki Miyoshi, Satoshi Murai, Tatsuya Sasaki, Jun Morimoto, Michiari Umakoshi, Masahiro Kameda, Takao Yasuhara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
abnormal posture
medicine.medical_specialty spinal alignment Deep brain stimulation Parkinson's disease medicine.medical_treatment Deep Brain Stimulation Pain Disease lumbago Lumbar Subthalamic Nucleus medicine Animals Humans Stage (cooking) Retrospective Studies business.industry Parkinson Disease medicine.disease Spinal surgery Neuromodulation (medicine) Surgery nervous system diseases Subthalamic nucleus Treatment Outcome neuromodulation Original Article Neurology (clinical) business |
| Zdroj: | Neurologia medico-chirurgica |
| ISSN: | 1349-8029 0470-8105 |
| Popis: | Parkinson's disease (PD) patients often suffer from spinal diseases requiring surgeries, although the risk of complications is high. There are few reports on outcomes after spinal surgery for PD patients with deep brain stimulation (DBS). The objective of this study was to explore the data on spinal surgery for PD patients with precedent DBS. We evaluated 24 consecutive PD patients with 28 spinal surgeries from 2007 to 2017 who received at least a 2-year follow-up. The characteristics and outcomes of PD patients after spinal surgery were compared to those of 156 non-PD patients with degenerative spinal diseases treated in 2013-2017. Then, the characteristics, outcomes, and spinal alignment of PD patients receiving DBS were analyzed in degenerative spinal/ lumbar diseases. The mean age at the time of spinal surgery was 68 years. The Hoehn and Yahr score regarding PD was stage 1 for 8 patients, stage 2 for 2 patients, stage 3 for 8 patients, stage 4 for 10 patients, and stage 5 for 0 patient. The median preoperative L-DOPA equivalent daily dose was 410 mg. Thirteen patients (46%) received precedent subthalamic nucleus (STN) DBS. Lumbar lesions with pain were common, and operation and anesthesia times were long in PD patients. Pain and functional improvement of PD patients persisted for 2 years after surgery with a higher complication rate than for non-PD patients. PD patients with STN DBS maintained better lumbar lordosis for 2 years after spinal surgery. STN DBS significantly maintained spinal alignment with subsequent pain and functional amelioration 2 years after surgery. The outcomes of spinal surgery for PD patients might be favorably affected by thorough treatment for PD including DBS. |
| Databáze: | OpenAIRE |
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