Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats
| Autor: | Sung Tae Kim, Ji Hoon Jeong, Jun Ho Lee, Tae Jin Lee, Eun Jung Kyung, Ho Sung Lee, Won Mo Lee, Eon Sub Park, Soo In Chae, Jung Sook Suh, Jinhyung Bae, Yoon Hee Chung, Uy Dong Sohn |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pain Threshold 0301 basic medicine Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Antineoplastic Agents Docetaxel Pharmacology Toxicology medicine.disease_cause Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals chemistry.chemical_classification Chemical Health and Safety business.industry Glutathione peroxidase Body Weight Public Health Environmental and Occupational Health Neurotoxicity Peripheral Nervous System Diseases General Medicine Glutathione medicine.disease Sciatic Nerve Rats Oxidative Stress Neuroprotective Agents 030104 developmental biology Nociception chemistry Phosphatidylcholines Sciatic nerve business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 41:476-485 |
| ISSN: | 1525-6014 0148-0545 |
| Popis: | Docetaxel is a taxane chemotherapeutic agent used in the treatment of breast cancer, prostate cancer and gastric cancer, but several side effects such as peripheral neurotoxicity could occur. The present study was designed to investigate the therapeutic potential of phosphatidylcholine (PC) on docetaxel-induced peripheral neurotoxicity. Rats were randomly divided into three groups and treated for 4 weeks. Behavioral tests were conducted to measure the effects of PC on docetaxel-induced decreases in mechanical & thermal nociceptive threshold. Biochemical tests were conducted to measure the level of oxidative stress on sciatic nerve. Histopathological and immunohistochemical experiments were also conducted to assess neuronal damage and glial activation. PC treatment significantly attenuated docetaxel-induced changes in mechanical & thermal nociceptive response latencies. PC decreased oxidative stress in sciatic nerve by increasing antioxidant levels (glutathione, glutathione peroxidase and superoxide dismutase activity). In immunohistochemical evaluation, PC treatment ameliorated docetaxel-induced neuronal damage and microglial activation in the sciatic nerve and spinal cord. Thus, PC showed protective effects against docetaxel-induced peripheral neurotoxicity. These effects may be attributed to its antioxidant properties and modulation of microglia. |
| Databáze: | OpenAIRE |
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