Stochastic Resonance Activity Influences Serum Tryptophan Metabolism in Healthy Human Subjects
| Autor: | Brenda Sedlnitzky-Semler, Nagy-Roland Badawi, Berthold Kepplinger, Halina Baran, Helene Erhart |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Kynurenine pathway Bioinformatics Biochemistry lcsh:Physiology lcsh:Biochemistry chemistry.chemical_compound Kynurenic acid kynurenic acid Internal medicine Anthranilic acid L-kynurenine Medicine lcsh:QD415-436 tryptophan stochastic resonance therapy Neurotransmitter Molecular Biology Original Research lcsh:QP1-981 exercise business.industry Tryptophan Metabolism medicine.disease Endocrinology Tryptophan Metabolite chemistry Parkinson’s disease business human activities serum dementia |
| Zdroj: | International Journal of Tryptophan Research : IJTR International Journal of Tryptophan Research, Vol 4 (2011) |
| ISSN: | 1178-6469 |
| Popis: | Background Stochastic resonance therapy (SRT) is used for rehabilitation of patients with various neuropsychiatric diseases. An alteration in tryptophan metabolism along the kynurenine pathway has been identified in the central and peripheral nervous systems in patients with neuroinflammatory and neurodegenerative diseases and during the aging process. This study investigated the effect of SRT as an exercise activity on serum tryptophan metabolites in healthy subjects. Methods Serum L-tryptophan, L-kynurenine, kynurenic acid, and anthranilic acid levels were measured one minute before SRT and at one, 5, 15, 30, and 60 minutes after SRT. We found that SRT affected tryptophan metabolism. Serum levels of L-tryptophan, L-kynurenine, and kynurenic acid were significantly reduced for up to 60 minutes after SRT. Anthranilic acid levels were characterized by a moderate, non significant transient decrease for up to 15 minutes, followed by normalization at 60 minutes. Tryptophan metabolite ratios were moderately altered, suggesting activation of metabolism after SRT. Lowering of tryptophan would generally involve activation of tryptophan catabolism and neurotransmitter, protein, and bone biosynthesis. Lowering of kynurenic acid by SRT might be relevant for improving symptoms in patients with neuropsychiatric disorders, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and depression, as well as certain pain conditions. |
| Databáze: | OpenAIRE |
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