Participation of complement in the nonimmune host defense against experimental Haemophilus influenzae type b septicemia and meningitis
| Autor: | F J Crosson, J A Winkelstein, E R Moxon |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Aging
Immunology Biology medicine.disease_cause Microbiology Haemophilus influenzae Sepsis Cerebrospinal fluid medicine Animals Mortality Meningitis Haemophilus Complement component 5 Innate immune system Complement C5 Complement C3 Complement System Proteins medicine.disease Complement system Rats Infectious Diseases Bacteremia Parasitology Meningitis Snake Venoms Research Article |
| Zdroj: | Infection and immunity. 14(4) |
| ISSN: | 0019-9567 |
| Popis: | This study was undertaken to determine whether the terminal complement components (C3-9) are involved in the nonimmune host defense against Haemophilus influenzae type b septicemia and meningitis. Using cobra venom factor, infant rats were depleted of C3 and C5. After intranasal challenge with H. influenzae type b, the complement-depleted rats developed a greater incidence and magnitude of bacteremia and a higher mortality rate. In contrast to the effects on bacteremia, complement depletion did not directly influence either the occurrence of meningitis or bacterial multiplication within the cerebrospinal fluid. These experiments provide evidence that the complement system may be an important mechanism of natural immunity to H. influenzae type b. |
| Databáze: | OpenAIRE |
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