Association of circulating exosomal miR-122 levels with BAT activity in healthy humans
| Autor: | Mami Matsushita, Ayumi Tsubota, Yuko Okamatsu-Ogura, Kazuki Nagaya, Masayuki Saito, Jussiaea Valente Bariuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Microarray lcsh:Medicine 030209 endocrinology & metabolism Standardized uptake value Exosomes Article Body Mass Index Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adipose Tissue Brown Fluorodeoxyglucose F18 Internal medicine microRNA Brown adipose tissue medicine MiR-122 Humans Obesity lcsh:Science Multidisciplinary Triglyceride business.industry lcsh:R medicine.disease Metabolic syndrome Healthy Volunteers MicroRNAs 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Positron-Emission Tomography lcsh:Q business Energy Metabolism Tomography X-Ray Computed |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Brown adipose tissue (BAT) plays an important role in body fat accumulation and the regulation of energy expenditure. Since the role of miRNAs in the pathogenesis of obesity and related metabolic diseases is contentious, we analyzed exosomal miRNAs in serum of healthy subjects with special references to BAT activity and body fat level. Forty male volunteers aged 20–30 years were recruited. Their BAT activity was assessed by fluorodeoxyglucose positron emission tomography and computed tomography after 2 h of cold exposure and expressed as a maximal standardized uptake value (SUVmax). Exosomal miRNA levels was analyzed using microarray and real-time PCR analyses. The miR-122-5p level in the high BAT activity group (SUV ≧ 3) was 53% lower than in the low BAT activity group (SUVmax |
| Databáze: | OpenAIRE |
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