Organic Photo-Electrochemical Transistor-Based Biosensor: A Proof-of-Concept Study toward Highly Sensitive DNA Detection
| Autor: | Xierong Zeng, Hong Yuan Chen, Jiajun Song, Wei Ren, Hu Jin, Yi Fan Ruan, Jing-Juan Xu, Peng Lin, Weiwei Wei, Feng Yan, Wei Wei Zhao, Shanming Ke |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biomedical Engineering Pharmaceutical Science Nanoparticle Metal Nanoparticles Nanotechnology 02 engineering and technology Biosensing Techniques 010402 general chemistry 01 natural sciences law.invention Biomaterials law Quantum Dots Animals Humans Bioelectronics business.industry Transistor DNA Electrochemical Techniques 021001 nanoscience & nanotechnology 0104 chemical sciences Semiconductor Quantum dot Electrode Gold 0210 nano-technology business Biosensor Organic electrochemical transistor |
| Zdroj: | Advanced healthcare materials. 7(19) |
| ISSN: | 2192-2659 |
| Popis: | Organic bioelectronics have shown promising applications for various sensing purposes due to their significant advantages in term of high flexibility, portability, easy fabrication, and biocompatibility. Here, a new type of organic device, organic photo-electrochemical transistor (OPECT), is reported, which is the combination of an organic electrochemical transistor and a photo-electrochemical gate electrode modified with CdS quantum dots (QDs). Thanks to the inherent amplification function of the transistor, the OPECT-based biosensor exhibits much higher sensitivity than that of a traditional biosensor. The sensing mechanism of the OPECT is attributed to the charge transfer between the photosensitive semiconductor CdS QDs and the gate electrode. In an OPECT-based DNA sensor, target DNA is labeled with Au nanoparticles (NPs) and captured on the gate electrode, which can influence the charge transfer on the gate caused by the exciton-plasmon interactions between CdS QDs and Au NPs. Consequently, a highly sensitive and selective DNA sensor with a detection limit of around 1 × 10-15 m is realized. It is expected that OPECTs can be developed as a high-performance platform for numerous biological detections in the future. |
| Databáze: | OpenAIRE |
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