Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct
| Autor: | Dae Sung Ryu, Wooram Park, Jung-Hoon Park, Kun Yung Kim, Seung Ok Lee, Ho Young Song, Seong Hun Kim, Dong-Hyun Kim, Jeon Min Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
self-expandable metallic stent (SEMS) medicine.medical_treatment Urology tissue hyperplasia Pharmaceutical Science lcsh:RS1-441 02 engineering and technology 010402 general chemistry 01 natural sciences Silver nanoparticle Article Metal lcsh:Pharmacy and materia medica Restenosis biliary sludge medicine Biliary sludge Chemistry Bile duct Stent silver nanoparticles (AgNPs) Rabbit (nuclear engineering) Hyperplasia 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences medicine.anatomical_structure visual_art visual_art.visual_art_medium 0210 nano-technology anti-bacterial response |
| Zdroj: | Pharmaceutics, Vol 12, Iss 563, p 563 (2020) Pharmaceutics Volume 12 Issue 6 |
| ISSN: | 1999-4923 |
| Popis: | Recent therapeutic strategies to suppress restenosis after biliary stent placement are insufficient. Here, we demonstrate the usefulness of a self-expandable metal stent (SEMS), a stent mesh coated with silver nanoparticles (AgNPs), for suppression of both stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. The AgNP-coated SEMSs were prepared using a simple bio-inspired surface modification process. Then, the prepared SEMSs were successfully placed in 22 of 24 rabbits. Sludge formation in the AgNP-coated SEMS groups was significantly decreased compared to the control group on gross findings. Cholangiographic and histologic examinations demonstrated significantly decreased tissue hyperplasia in the AgNP-coated SEMS groups compared with the control group (p < 0.05 for all). There were no differences between the AgNP-coated SEMS groups (p > 0.05 for all). However, in the group coated with the greatest concentration of AgNPs (Group D), submucosal fibrosis was thicker than in the other AgNP-coated groups (p < 0.05 for all). The AgNP-coated metallic stent mesh significantly suppressed stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. Taken together, the AgNP coating strategy developed in this study could be widely utilized in non-vascular medical devices for anti-bacterial and anti-inflammatory responses. |
| Databáze: | OpenAIRE |
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