Clinical Relationship of Myocardial Sympathetic Nervous Activity to Cardiovascular Functions in Chronic Heart Failure: Assessment by Myocardial Scintigraphy with 123I-Metaiodobenzylguanidine
| Autor: | Satomi Fujiwara, Kazumasa Seiji, Tokihisa Kimura, Yukoh Wada, Masaetsu Miura, Shunpei Mori |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Cardiac output Sympathetic Nervous System Time Factors Blood Pressure Chemokine CXCL9 General Biochemistry Genetics and Molecular Biology Norepinephrine Internal medicine Heart rate medicine Humans Radionuclide Imaging Aged Heart Failure business.industry Myocardium Mediastinum Heart General Medicine Stroke volume Middle Aged medicine.disease Pulse pressure 3-Iodobenzylguanidine Blood pressure Mean blood pressure Echocardiography Heart failure Cardiology Intercellular Signaling Peptides and Proteins Female Radiopharmaceuticals business Chemokines CXC |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 201:261-270 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.201.261 |
| Popis: | The aim of this study was to clarify the relationship between cardiac sympathetic nervous activity (SNA) assessed by radioiodinated metaiodobenzylguanidine ( 1 2 3 I-MIBG), an analogue of norepinephrine and cardiovascular functions in patients with chronic heart failure (CHF). Subjects were 17 patients with CHF. A dose of 111 MBq of 1 2 3 I-MIBG was administered intravenously, and 5-minute anterior planar images were obtained 15 minutes (early image) and 3 hours (delayed image) after the injection. The heart/mediastinum (H/M) count ratio was defined to quantify cardiac 1 2 3 I-MIBG uptake. The washout ratio (WR) of 1 2 3 I-MIBG from the heart was calculated as follows: (early counts-delayed counts)/early counts × 100 (%). Echocardiography was performed on all patients within 1 week of 1 2 3 I-MIBG scintigraphy to measure stroke volume index (SVI). Blood pressure and heart rate (HR) in the resting state were also recorded to calculate cardiovascular functions including cardiac output, pulse pressure (PP), and mean blood pressure. Significant linear correlations were found between the early H/M ratio of 1 2 3 I-MIBG and SVI, and between the delayed H/M ratio of 1 2 3 I-MIBG and SVI, respectively. WR of 1 2 3 I-MIBG was correlated with HR, and was inversely correlated with SVI and with PP, respectively. It is likely that a decrease in SVI is associated with enhanced cardiac SNA in severe CHF. 1 2 3 I-MIBG scintigraphy is effective in assessing the cardiac functional status and SNA in patients with CHF in vivo. Moreover, changes in PP and HR indicate well alteration in SNA. |
| Databáze: | OpenAIRE |
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