An enzymatic approach to bifunctional chelating agents
| Autor: | Giovanni B. Giovenzana, Luciano Lattuada, Ivan Guglielmo Menegotto, Paolo Minazzi |
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| Rok vydání: | 2014 |
| Předmět: |
Denticity
Swine Aspergillus oryzae Buffers Ligands Biochemistry chemistry.chemical_compound Hydroxides Animals Organic chemistry Chelation Physical and Theoretical Chemistry Chemoselectivity Bifunctional Candida Chelating Agents chemistry.chemical_classification Ligand Chemistry Hydrolysis Biomolecule Organic Chemistry Lipase Enzymes Kinetics Enzyme Functional group Solvents Thermodynamics |
| Zdroj: | Org. Biomol. Chem.. 12:6915-6921 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c4ob00810c |
| Popis: | Bifunctional chelating agents (BFCAs) combine the complexing properties of a multidentate ligand with the presence of a free reactive functional group, mainly devoted to conjugation purposes. Indeed, products obtained by conjugation of a BFCA to a biomolecule and coordination of a suitable metal ion are widely applied in medicine nowadays as diagnostic and therapeutic agents. BFCAs are generally prepared through multi-step syntheses and with extensive application of protection-deprotection strategies, due to the large number of functional groups involved. Hydrolytic enzymes, with their unique chemoselectivity, provided the best results in the preparation of three different BFCAs based on very useful and well known ligand platforms. |
| Databáze: | OpenAIRE |
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