I danas nepoznati aspekti patogeneze nekrotičnog enteritisa živine

Autor: Dubravka Milanov, Milica Živkov Baloš, Nevenka Aleksić, Slobodan Knežević, Marko Pajić
Rok vydání: 2019
Předmět:
Zdroj: Archives of Veterinary Medicine, Vol 12, Iss 1 (2019)
Archives of Veterinary Medicine
Archives of Veterinary MedicineAVM
ISSN: 2683-4138
1820-9955
DOI: 10.46784/e-avm.v12i1.38
Popis: Necrotic enteritis (NE) or poultry clostridiosis is a disease which poses enormous health problems and makes tremendous economic losses to intensive poultry production worldwide. Despite having been targeted in extensive research for decades, a number of aspects of its pathogenesis remain unknown. For more than 30 years alfa-toxin has been considered to be the main virulence factor of the causative agent, but experimental research using a mutant Clostridium perfringens strain lacking the gene coding for this confirmed that alpha-toxin is not necessary for pathogenesis. Since the 1980s, NetB toxin has been the main suspected virulence factor. However, recently it has been discovered that the large clostridial cytotoxin named TpeL also contributes to the pathogenesis of NE. In spite of that, the prevalence of the genes which code for these toxins vary between the isolates of C. perfringens from the intestines of diseased poultry, which made clear that further investigation into their roles is necessary. It has been agreed that specific intestinal environmental conditions, which favour the growth and multiplication of C. perfringens, are key factors to the emergence of disease. Given that a battery of non-specific factors contributes to pathogenesis, as well as that it is impossible to eliminate them in intensive poultry production, not much hope remains that NE can be controlled. In this short review, the current knowledge on the pathogenesis of NE has been summarized. Nekrotični enteritis (NE) ili klostridioza živine, predstavlja veliki zdravstveni problem i nanosi ogromne ekonomske gubitke intenzivnoj živinarskoj proizvodnji širom sveta. Brojni aspekti patogeneze NE su i danas nepoznati, uprkos tome što su decenijama predmet intenzivnih izučavanja. Više od 30 godina je alfa-toksin razmatran kao glavni faktor virulencije uzročnika, ali su eksperimentalna istraživanja primenom mutantnog soja Clostridium perfringens, koji nema gen koji kodira sintezu alfa-toksina, pot-vrdila da ovaj toksin nije neophodan za nastanak bolesti. Od osamdesetih godina prošlog veka, NetB toksin je “glavni osumnjičeni” faktor virulencije, a od nedavno se smatra da i veliki klostridijalni ekstracelularni citotoksin, koji je nazvan TpeL, doprinosi patogenezi NE. Međutim, prevalencija gena koji kodiraju ove toksine, veoma varira kod izolata C. perfringens iz creva obolele živine i jasno je da su neophodna dodatna ispitivanja njihove ul-oge. Saglasnost postoji da su za pojavu bolesti ključni specifi čni uslovi u crevima koji pogoduju rastu i umnožavanju C. perfringens. Ako uzmemo u obzir da niz nespecifi čnih faktora tome doprinosi, kao i da ih je praktično nemoguće u potpunosti otkloniti u intenzivnoj živinarskoj proizvodnji, ne ostaje mnogo nade da je nekrotični enteritis moguće staviti pod kontrolu. U radu ukratko sumiramo trenutna stanovišta o patogenezi NE živine.
Databáze: OpenAIRE
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