The effects of atrial natriuretic peptide on electroconvulsive shock-induced amnesia in rats. Transmitter-mediated action
| Autor: | G. Telegdy, Amelia Bidzseranova, Botond Penke, Géza Tóth |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Atropine
Male medicine.medical_specialty Phenoxybenzamine Methysergide Amnesia (+)-Naloxone Propranolol Bicuculline Cellular and Molecular Neuroscience Endocrinology Atrial natriuretic peptide Memory Internal medicine Avoidance Learning Haloperidol Animals Medicine Electroshock Naloxone Endocrine and Autonomic Systems business.industry General Medicine Rats Neurology medicine.symptom business Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Neuropeptides. 19:103-106 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/0143-4179(91)90139-a |
| Popis: | Electroconvulsive shock (ECS) applied immediately after passive avoidance learning in rats caused partial amnesia. This could be prevented by administering r-ANP into the lateral brain ventricle. The effects of pre-treatment with different receptor blockers: (haloperidol, atropine, phenoxybenzamine, propranolol, naloxone, bicuculline and methysergide) on the ANP-induced antiamnesia were investigated. The receptor blockers per se in the doses selected had no influence on the ECS-induced amnesia. Haloperidol, atropine and propranolol blocked the antiamnestic action of the peptide, while phenoxybenzamine, naloxone, bicuculline and methysergide were ineffective. The results confirm our previous observations that ANP might play a role in learning and memory processes and also suggest that the antiamnestic action of the peptide is mediated by dopaminergic, cholinergic and beta-adrenergic mediator systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|