Depressive Symptoms are Associated with Progression to Dementia in Patients with Amyloid-Positive Mild Cognitive Impairment

Autor: Seongheon Kim, Alzheimer’s Disease Neuroimaging Initiative, Jae-Won Jang, Young Chul Youn, SangYun Kim, Jae-Sung Lim, Young Ho Park, Byungseung Moon
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Disease
Neuropsychological Tests
03 medical and health sciences
Imaging
Three-Dimensional
0302 clinical medicine
Neuroimaging
Surveys and Questionnaires
Internal medicine
mental disorders
Humans
Medicine
Dementia
Cognitive Dysfunction
Risk factor
Cognitive decline
Depression (differential diagnoses)
Aged
Aged
80 and over
Psychiatric Status Rating Scales
Amyloid beta-Peptides
Aniline Compounds
030214 geriatrics
Depression
business.industry
General Neuroscience
General Medicine
medicine.disease
Magnetic Resonance Imaging
Cognitive test
Psychiatry and Mental health
Clinical Psychology
Positron-Emission Tomography
Disease Progression
Ethylene Glycols
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Neuropsychiatric Inventory Questionnaire
Zdroj: Journal of Alzheimer's Disease. 58:1255-1264
ISSN: 1875-8908
1387-2877
Popis: Background Depressive symptoms are prevalent in patients with mild cognitive impairment (MCI) and are considered to be a risk factor for progression to dementia. Objective The purpose of this study was to evaluate whether depressive symptoms in MCI promote disease progression in a manner related to amyloid status, and to determine the relationship between depressive symptoms and longitudinal cerebral structural changes. Methods Baseline data for 336 patients with MCI (75 with depression and 261 without) from the Alzheimer's Disease Neuroimaging Initiative study were analyzed. All participants underwent comprehensive cognitive testing, volumetric magnetic resonance imaging (MRI), and [18F]AV45 positron emission tomography amyloid imaging. Depressive symptoms were measured using the Neuropsychiatric Inventory Questionnaire. A voxel-based morphometric analysis using volumetric brain MRI data was used to compare longitudinal structural changes related to depressive symptoms. Results The conversion rate to dementia was different between patients with and without depression in amyloid-positive MCI (40.8% versus 19.7%, respectively; p = 0.006). Patients who were amyloid-positive at baseline also exhibited a greater degree of 2-year cognitive decline. Depression in amyloid-positive MCI was associated with longitudinal cortical atrophy in the left cingulate gyrus. Conclusion Our study indicates that the presence of depressive symptoms in patients with amyloid-positive MCI is associated with higher progression to dementia and longitudinal cortical atrophy.
Databáze: OpenAIRE
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