External validity of two nomograms for predicting distant brain failure after radiosurgery for brain metastases in a bi-institutional independent patient cohort
| Autor: | Katherine R. Miller, Robert H. Press, Roshan S. Prabhu, C. Fasola, Anthony L. Asher, Danielle Boselli, Hui-Kuo Shu, R.J. McCammon, John H. Heinzerling, Kirtesh R. Patel, Scott P. Lankford, Ashley Sumrall, Walter J. Curran, Stuart H. Burri, Benjamin J. Moeller |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty genetic structures medicine.medical_treatment Recursive partitioning Radiosurgery urologic and male genital diseases Cohort Studies External validity Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine 030212 general & internal medicine Aged Aged 80 and over Brain Neoplasms business.industry Reproducibility of Results Middle Aged Nomogram Nomograms Treatment Outcome Increased risk Neurology 030220 oncology & carcinogenesis Cohort Female Neurology (clinical) business Validation cohort |
| Zdroj: | Journal of Neuro-Oncology. 137:147-154 |
| ISSN: | 1573-7373 0167-594X |
| Popis: | Patients treated with stereotactic radiosurgery (SRS) for brain metastases (BM) are at increased risk of distant brain failure (DBF). Two nomograms have been recently published to predict individualized risk of DBF after SRS. The goal of this study was to assess the external validity of these nomograms in an independent patient cohort. The records of consecutive patients with BM treated with SRS at Levine Cancer Institute and Emory University between 2005 and 2013 were reviewed. Three validation cohorts were generated based on the specific nomogram or recursive partitioning analysis (RPA) entry criteria: Wake Forest nomogram (n = 281), Canadian nomogram (n = 282), and Canadian RPA (n = 303) validation cohorts. Freedom from DBF at 1-year in the Wake Forest study was 30% compared with 50% in the validation cohort. The validation c-index for both the 6-month and 9-month freedom from DBF Wake Forest nomograms was 0.55, indicating poor discrimination ability, and the goodness-of-fit test for both nomograms was highly significant (p |
| Databáze: | OpenAIRE |
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