Optical resolution photoacoustic microscopy using novel high-repetition-rate passively Q-switched microchip and fiber lasers
| Autor: | Robert Fedosejevs, Lei Pan, Yogesh Godwal, Janaka C. Ranasinghesagara, Wei Shi, Shaun Kerr, Ilya Utkin, Roger J. Zemp |
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| Rok vydání: | 2010 |
| Předmět: |
Diagnostic Imaging
Materials science Optical Phenomena Biomedical Engineering Microscopy Acoustic Lasers Solid-State law.invention Biomaterials Optics law Fiber laser Humans Image resolution Photoacoustic spectroscopy business.industry Pulse (signal processing) Phantoms Imaging Resolution (electron density) Equipment Design Laser Q-switching Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Transducer Optoelectronics business |
| Zdroj: | Journal of biomedical optics. 15(5) |
| ISSN: | 1560-2281 |
| Popis: | Optical-resolution photoacoustic microscopy (OR-PAM) is a novel imaging technology for visualizing optically absorbing superficial structures in vivo with lateral spatial resolution determined by optical focusing rather than acoustic detection. Since scanning of the illumination spot is required, OR-PAM imaging speed is limited by both scanning speed and laser pulse repetition rate. Unfortunately, lasers with high repetition rates and suitable pulse durations and energies are not widely available and can be cost-prohibitive and bulky. We are developing compact, passively Q-switched fiber and microchip laser sources for this application. The properties of these lasers are discussed, and pulse repetition rates up to 100 kHz are demonstrated. OR-PAM imaging was conducted using a previously developed photoacoustic probe, which enabled flexible scanning of the focused output of the lasers. Phantom studies demonstrate the ability to image with lateral spatial resolution of 7±2 µm with the microchip laser system and 15±5 µm with the fiber laser system. We believe that the high pulse repetition rates and the potentially compact and fiber-coupled nature of these lasers will prove important for clinical imaging applications where real-time imaging performance is essential. |
| Databáze: | OpenAIRE |
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