Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice
| Autor: | Wenyue Zhuang, He Li, Zijing Qiao, Jin-Ying Che, Chunmei Wang, Jinghui Sun, Jianguang Chen, Shuo Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine NF-E2-Related Factor 2 Schisandra chinensis Interleukin-1beta Pharmacology Antioxidants Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polysaccharides Malondialdehyde medicine Animals Aspartate Aminotransferases Acetaminophen Schisandra Liver injury Mice Inbred ICR Glycogen Synthase Kinase 3 beta biology Caspase 3 Plant Extracts Superoxide Dismutase lcsh:RM1-950 Alanine Transaminase Glutathione biology.organism_classification medicine.disease Oxidative Stress lcsh:Therapeutics. Pharmacology 030104 developmental biology Liver Proto-Oncogene Proteins c-bcl-2 chemistry Hepatoprotection Carbon tetrachloride Molecular Medicine Chemical and Drug Induced Liver Injury Heme Oxygenase-1 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 248-254 (2019) |
| ISSN: | 1347-8613 |
| Popis: | Schisandra chinensis is a hepatoprotective herb that has been used for centuries in China. Polysaccharide is one of the major active components in S. chinensis, which has been reported to improve liver injuries induced by carbon tetrachloride, alcohol, or high-fat diet. In this study, we observed the effects and corresponding mechanisms of the secondary component of Schisandra polysaccharide (acidic polysaccharide, SCAP) on a murine model of severe acute liver injury induced by acetaminophen (APAP). SCAP significantly decreased the serum alanine aminotransferase (ALT), aspartate aminotransferas (AST), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels, and was found to alleviate hepatic pathological alterations in the mouse model. Meanwhile, SCAP revealed a protective effects on the liver injury-related enzymes and factors, such as significantly diminished malondialdehyde (MDA) levels and glutathione (GSH) depletion, reduced ratio of B-cell lymphoma-2 (Bcl-2)-associated X protein (Bax)/Bcl-2, prohibited cleaved caspase-3 expression, and elevated the expression of p-AMPK, p-Akt, p-glycogen synthase kinase 3β (GSK 3β), nuclear factor erythroid 2–derived-like 2 (Nrf 2) and heme oxygenase-1 (HO-1) proteins in the liver tissues of the mouse model. In conclusion, we speculated that the protective activities of SCAP on the APAP-induced mouse model of acute liver injury might be related to its antioxidation, anti-inflammation and anti-apoptosis properties. Keywords: Schisandra chinensis, Polysaccharide, Hepatoprotection, Antioxidation |
| Databáze: | OpenAIRE |
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