Apomorphine effects on brain metabolism in neuroleptic-naive schizophrenic patients
| Autor: | S Franco, E.S. Garnett, Gregory M. Brown, Claude Nahmias, John M. Cleghorn, Henry Szechtman, Barbara Szechtman, Ronald D. Kaplan |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Psychosis Adolescent Apomorphine medicine.medical_treatment Central nervous system Neuroscience (miscellaneous) Carbohydrate metabolism Deoxyglucose Dopamine agonist Receptors Dopamine Fluorodeoxyglucose F18 Internal medicine Post-hoc analysis Neural Pathways medicine Humans Radiology Nuclear Medicine and imaging Dominance Cerebral Saline Cerebral Cortex Psychiatric Status Rating Scales Brain medicine.disease Corpus Striatum Psychiatry and Mental health Endocrinology medicine.anatomical_structure Schizophrenia Female Schizophrenic Psychology Psychology Energy Metabolism medicine.drug Tomography Emission-Computed |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0165-1781 |
| Popis: | Since neuroleptic treatment produces a significant increase in striatal metabolism relative to cortical metabolism, we wished to determine whether the dopamine agonist apomorphine (APO) might have the opposite effect, and whether it would discriminate schizophrenic patients from healthy controls. Eleven neuroleptic-naive schizophrenic patients (diagnosed according to DSM-III) and eight normal subjects were compared with respect to cerebral accumulation of 18F-fluorodeoxyglucose measured by positron emission tomography following APO, 0.75 mg 70 kg (weight adjusted), or saline. Relative striatal glucose metabolism decreased significantly after APO in schizophrenic patients but not in control subjects. Post hoc analysis of data in 12 other regions revealed that relative superior temporal metabolism decreased very slightly, but significantly, in schizophrenic patients but not in control subjects after APO, and that the posterior frontal region increased in control subjects but not in the patient group. |
| Databáze: | OpenAIRE |
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