Mycobacterium bovis BCG Vaccination as Prophylaxis against Mycobacterium ulcerans Osteomyelitis in Buruli Ulcer Disease
| Autor: | Françoise Portaels, A. Guedenon, Claude Zinsou, Martine Debacker, C. Steunou, J. Aguiar, Wayne M. Meyers |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Buruli ulcer medicine.medical_specialty Tuberculosis Adolescent Immunology Mycobacterium Infections Nontuberculous Scars Microbiology Skin Ulcer medicine Humans Child Mycobacterium ulcerans biology business.industry Osteomyelitis Vaccination Skin ulcer medicine.disease biology.organism_classification Dermatology Surgery Infectious Diseases Child Preschool Microbial Immunity and Vaccines BCG Vaccine Female Parasitology medicine.symptom business BCG vaccine |
| Zdroj: | Infection and Immunity. 72:62-65 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.72.1.62-65.2004 |
| Popis: | Mycobacterium ulcerans disease, or Buruli ulcer (BU), causes significant morbidity in West Africa. Clinically, the disease presents in the skin as either nonulcerative or ulcerative forms and often invades bones either subjacent to the skin lesion (contiguous osteomyelitis) or remote from the skin lesion (metastatic osteomyelitis). Osteomyelitis represents a severe form of the disease that often requires numerous surgical interventions, even amputations. Surgery is accepted as the present definitive treatment for BU. In the absence of an effective drug treatment, the need for the development of preventive and control strategies becomes paramount. No specific vaccine, however, is presently available for BU. Of 372 consecutive patients in Benin presenting with BU (confirmed by microbiological and histopathological analyses) whose Mycobacterium bovis BCG scar statuses were known, 196 children (M. ulcerans osteomyelitis in children and adults. Therefore, health authorities should give attention to the enhancement of neonatal BCG vaccination coverage in all countries of Africa where BU is endemic. Protection against severe forms of BU and childhood tuberculosis would likewise be improved by this intervention. |
| Databáze: | OpenAIRE |
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