Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons
| Autor: | Hitoshi Morikawa, Mark T. Harnett, Kee Chan Ahn, Brian E. Bernier |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Time Factors Dopamine Neuroscience(all) Long-Term Potentiation Biophysics Action Potentials Inositol 1 4 5-Trisphosphate In Vitro Techniques Biology Receptors N-Methyl-D-Aspartate Article MOLNEURO Methoxyhydroxyphenylglycol Rats Sprague-Dawley chemistry.chemical_compound Mesencephalon Neural Pathways medicine LTP induction Animals Enzyme Inhibitors Neurotransmitter Neurons Neuronal Plasticity Dose-Response Relationship Drug General Neuroscience musculoskeletal neural and ocular physiology Intracellular Signaling Peptides and Proteins Long-term potentiation Electric Stimulation Peptide Fragments Rats Metabotropic receptor medicine.anatomical_structure 2-Amino-5-phosphonovalerate Gene Expression Regulation chemistry nervous system Excitatory postsynaptic potential NMDA receptor Calcium CELLBIO Neuron Excitatory Amino Acid Antagonists Neuroscience medicine.drug |
| Zdroj: | Neuron. 62(6):826-838 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2009.05.011 |
| Popis: | Summary Bursts of spikes triggered by sensory stimuli in midbrain dopamine neurons evoke phasic release of dopamine in target brain areas, driving reward-based reinforcement learning and goal-directed behavior. NMDA-type glutamate receptors (NMDARs) play a critical role in the generation of these bursts. Here we report LTP of NMDAR-mediated excitatory transmission onto dopamine neurons in the substantia nigra. Induction of LTP requires burst-evoked Ca 2+ signals amplified by preceding metabotropic neurotransmitter inputs in addition to the activation of NMDARs themselves. PKA activity gates LTP induction by regulating the magnitude of Ca 2+ signal amplification. This form of plasticity is associative, input specific, reversible, and depends on the relative timing of synaptic input and postsynaptic bursting in a manner analogous to the timing rule for cue-reward learning paradigms in behaving animals. NMDAR plasticity might thus represent a potential neural substrate for conditioned dopamine neuron burst responses to environmental stimuli acquired during reward-based learning. |
| Databáze: | OpenAIRE |
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