Elevated unmethylated and methylated insulin DNA are unique markers of A + β + ketosis prone diabetes

Autor:	Raghavendra G. Mirmira, Ashok Balasubramanyam, Surya N. Mulukutla, Sarah A. Tersey, Christiane S. Hampe
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty Diabetic ketoacidosis Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Systemic inflammation Article Diabetic Ketoacidosis Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin-Secreting Cells Internal medicine Diabetes mellitus Internal Medicine medicine Humans Insulin business.industry DNA DNA Methylation medicine.disease Up-Regulation Diabetes Mellitus Type 1 030104 developmental biology Diabetes Mellitus Type 2 chemistry Female medicine.symptom Beta cell business Biomarkers Ketosis-prone diabetes
Zdroj:	Journal of Diabetes and its Complications. 32:193-195
ISSN:	1056-8727
Popis:	A + β + ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A + β + KPD compared to all other KPD subgroups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa11453b8db8c5050e52412f5995b22 https://doi.org/10.1016/j.jdiacomp.2017.10.013 Zobrazit plný text záznamu Full Text from ScienceDirect