Large variations in skeletal muscle carnitine level fail to modify energy metabolism in exercising rats
| Autor: | M. H. Mayet, B. Sempore, B. Simi, Roland Favier |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Glycogenolysis Physical Exertion Physical exercise Endogeny Biology chemistry.chemical_compound Carnitine Internal medicine medicine Animals Muscles Skeletal muscle Rats Inbred Strains Stereoisomerism General Medicine Metabolism Rats Endocrinology medicine.anatomical_structure Liver chemistry Energy Metabolism Primary Carnitine Deficiency medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part A: Physiology. 97:543-549 |
| ISSN: | 0300-9629 |
| DOI: | 10.1016/0300-9629(90)90125-c |
| Popis: | 1. 1. The importance of carnitine status in energy metabolism during exercise was studied in experimentally carnitine-depleted or supplemented rats. 2. 2. Muscle carnitine concentration can be decreased by 40% with D-carnitine and increased by 40% with l -carnitine supplementation. 3. 3. In spite of large variation of carnitine content, neither the exercising capacity nor the rate of muscle or liver glycogenolysis were modified during submaximal exercise. 4. 4. The increased lipid metabolism induced by exercise can be adequately supported by endogenous levels of tissue carnitine. 5. 5. Before any impairment in energy metabolism during exercise can be demonstrated, carnitine concentration has to be reduced to a level close to that measured with primary carnitine deficiency, i.e. less than 20μmol/l of plasma. |
| Databáze: | OpenAIRE |
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