Effect of a drug holiday on plasma chlorpromazine levels in chronic schizophrenic patients
| Autor: | Thomas E. Gift, Linda A. Hershey, Leonor Rivera-Calimlim, Robert W. Atkins |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Autonomic function Chlorpromazine Pharmacology toxicology Phenothiazines parasitic diseases medicine Humans Parkinson Disease Secondary Pharmacology Extrapyramidal signs business.industry Drug holiday Middle Aged medicine.disease humanities Substance Withdrawal Syndrome Schizophrenia Anesthesia Chronic Disease business human activities medicine.drug |
| Zdroj: | Psychopharmacology. 73:355-358 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00426465 |
| Popis: | Low chloropromazine (CPZ) levels have been measured in chronically treated schizophrenics. We tested six such patients to determine whether a 2-week CPZ-free period (drug holiday) would improve plasma CPZ levels. We also monitored psychiatric symptoms, autonomic function, and extrapyramidal signs. We found these patients to have low predose CPZ levels that did not change appreciably after the drug holiday. Peak levels following the holiday averaged 28 +/- 7 ng/ml higher than those measured prior to the holiday. Drug holidays are safe and should be examined more thoroughly as a means of improving plasma neuroleptic levels in chronically treated schizophrenics. |
| Databáze: | OpenAIRE |
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