| Autor: |
Hugo Pinto-Marques, Joana Cardoso, Sílvia Silva, João L. Neto, Maria Gonçalves-Reis, Daniela Proença, Marta Mesquita, André Manso, Sara Carapeta, Mafalda Sobral, Antonio Figueiredo, Clara Rodrigues, Adelaide Milheiro, Ana Carvalho, Rui Perdigoto, Eduardo Barroso, José B. Pereira-Leal |
| Přispěvatelé: |
Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Annals of surgery. 276(5) |
| ISSN: |
1528-1140 |
| Popis: |
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. OBJECTIVE: To propose a new decision algorithm combining biomarkers measured in a tumor biopsy with clinical variables, to predict recurrence after liver transplantation (LT). SUMMARY BACKGROUND DATA: Liver cancer is one of the most frequent causes of cancer-related mortality. LT is the best treatment for hepatocellular carcinoma (HCC) patients but the scarcity of organs makes patient selection a critical step. Additionally, clinical criteria widely applied in patient eligibility decisions miss potentially curable patients while selecting patients that relapse after transplantation. METHODS: A literature systematic review singled out candidate biomarkers whose RNA levels were assessed by quantitative PCR in tumor tissue from 138 HCC patients submitted to LT (>5 y follow up, 32% beyond Milan criteria). The resulting four gene signature was combined with clinical variables to develop a decision algorithm using machine learning approaches. The method was named HepatoPredict. RESULTS: HepatoPredict identifies 99% disease-free patients (>5 y) from a retrospective cohort, including many outside clinical criteria (16%-24%), thus reducing the false negative rate. This increased sensitivity is accompanied by an increased positive predictive value (88,5%-94,4%) without any loss of long-term overall survival or recurrence rates for patients deemed eligible by HepatoPredict; those deemed ineligible display marked reduction of survival and increased recurrence in the short and long term. CONCLUSIONS: HepatoPredict outperforms conventional clinical-pathologic selection criteria, (Milan, UCSF) providing superior prognostic information. Accurately identifying which patients most likely benefit from LT enables an objective stratification of waiting lists and information-based allocation of optimal versus suboptimal organs. publishersversion published |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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