Synthesis andIn VitroUrease Inhibition of Some Novel Benzimidazole‐based Hydrazones

Autor:	Bahar Bilgin Sökmen, Emre Menteşe
Přispěvatelé:	Belirlenecek
Rok vydání:	2019
Předmět:	Benzimidazole chemistry.chemical_compound Urease biology Chemistry Organic Chemistry biology.protein Combinatorial chemistry In vitro
Zdroj:	Journal of Heterocyclic Chemistry. 56:2442-2448
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.3632
Popis:	WOS: 000479700000001 A novel series of N '-(substituted benzylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides and N '-(1-(substituted phenyl)ethylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. All newly synthesized compounds were found to exhibit potent inhibitory properties against urease enzyme in the range of IC50 = 0.0155 +/- 0.0039-0.0602 +/- 0.0071 mu M, when compared with the thiourea as standard (IC50 = 0.5115 +/- 0.0233 mu M). All target molecules were characterized by H-1-NMR, C-13-NMR, IR, and electrospray ionization mass spectrometry.
Databáze:	OpenAIRE
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