Human rhinovirus infection during naturally occurring COPD exacerbations
| Autor: | Gavin C. Donaldson, Raymond J. Sapsford, Anant R.C. Patel, Alexander J. Mackay, Richa Singh, SN George, Davinder S. Garcha, Jadwiga A. Wedzicha |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Rhinovirus Exacerbation Vital Capacity medicine.disease_cause Polymerase Chain Reaction Pulmonary Disease Chronic Obstructive stomatognathic system Recurrence Interquartile range Forced Expiratory Volume Internal medicine London Prevalence otorhinolaryngologic diseases medicine Humans Prospective Studies Aged Asthma COPD Picornaviridae Infections medicine.diagnostic_test business.industry Smoking Sputum virus diseases Bacterial Infections Middle Aged medicine.disease Haemophilus influenzae Streptococcus pneumoniae Treatment Outcome Immunology Bronchitis Female medicine.symptom business Moraxella catarrhalis circulatory and respiratory physiology |
| Zdroj: | European Respiratory Journal. 44:87-96 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00223113 |
| Popis: | Human rhinovirus (HRV) infection is an important trigger of exacerbations of chronic obstructive pulmonary disease (COPD) but its role in determining exacerbation frequency phenotype or the time-course of HRV infection in naturally occurring exacerbations is unknown. Sputum samples from 77 patients were analysed by real-time quantitative PCR for both HRV (388 samples), and Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis (89 samples). Patients recorded worsening of respiratory symptoms on daily diary cards, from which exacerbations were identified. HRV prevalence and load at exacerbation presentation were significantly higher than in the stable state (prevalence 53.3% versus 17.2%, respectively; p |
| Databáze: | OpenAIRE |
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