Current Applications and Future Perspectives of CRISPR-Cas9 for the Treatment of Lung Cancer
| Autor: | Endeshaw Chekol Abebe, Medhin, Markeshaw Tiruneh G, Tadesse Asmamaw Dejenie, Tekeba Sisay, Tesfahun Bekele, Nega Berhane |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Review cancer treatment 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology medicine cancer Immunology and Allergy CRISPR Pharmacology (medical) Epidermal growth factor receptor Cas9 Lung cancer biology business.industry CRISPR-Cas9 technology Gastroenterology RNA Cancer medicine.disease lung cancer 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research biology.protein business |
| Zdroj: | Biologics : Targets & Therapy |
| ISSN: | 1177-5491 |
| Popis: | Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins are referred to as CRISPR-Cas9. Bacteria and archaea have an adaptive (acquired) immune system. As a result, developing the best single regulated RNA and Cas9 endonuclease proteins and implementing the method in clinical practice would aid in the treatment of diseases of various origins, including lung cancers. This seminar aims to provide an overview of CRISPR-Cas9 technology, as well as current and potential applications and perspectives for the method, as well as its mechanism of action in lung cancer therapy. This technology can be used to treat lung cancer in two different ways. The first approach involves creating single directed RNA and Cas9 proteins and then distributing them to cancer cells using suitable methods. Single directed RNA looks directly at the lung’s mutated epidermal growth factor receptor and makes a complementary match, which is then cleaved with Cas9 protein, slowing cancer progression. The second method is to manipulate the expression of ligand-receptors on immune lymphocytic cells. For example, if the CRISPR-Cas9 system disables the expression of cancer receptors on lymphocytes, it decreases the contact between the tumor cell and its ligand-receptor, thus slowing cancer progression. |
| Databáze: | OpenAIRE |
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