Effects of calpain on antioxidant enzyme activities
| Autor: | Peter Johnson, Janet L. Hammer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Antioxidant
medicine.medical_treatment Glutathione reductase Carnosine Biochemistry Antioxidants Superoxide dismutase chemistry.chemical_compound In vivo medicine Animals Peptide Synthases chemistry.chemical_classification Glutathione Peroxidase biology Calpain Superoxide Dismutase Glutathione peroxidase General Medicine Catalase Glutathione Reductase chemistry biology.protein |
| Zdroj: | Free radical research. 21(1) |
| ISSN: | 1071-5762 |
| Popis: | The activities of superoxide dismutase, catalase and glutathione reductase were not affected by in vitro incubation with the intracellular proteinase calpain, suggesting that these enzymes are not in vivo substrates of calpain. In contrast, the activity of another important antioxidant enzyme, glutathione peroxidase, is stimulated in vitro by calpain. This may explain the correlation between elevations in glutathione peroxidase activity and calpain activity which occur in aging, exercised and dystrophic muscle. Calpain treatment in vitro caused a large decrease in the activity of carnosine synthetase which is involved in the synthesis of the putative antioxidant carnosine. This may be the reason for the in vivo correlation between elevated calpain and diminished carnosine levels in aging, hypertensive, denervated and dystrophic muscles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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