Pulmonary artery denervation: a novel treatment modality for pulmonary hypertension
| Autor: | Soban Umar, Nir Hoftman, Trixie Le, C. Makar, Philip Morway |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Sympathetic nervous system medicine.medical_specialty Cardiac output business.industry Vascular disease Decreased cardiac output 030204 cardiovascular system & hematology medicine.disease Pulmonary hypertension Sudden cardiac death 03 medical and health sciences Editorial 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Internal medicine Hypoxic pulmonary vasoconstriction medicine.artery Pulmonary artery cardiovascular system medicine Cardiology business |
| Zdroj: | Journal of Thoracic Disease. 11:1094-1096 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2019.02.93 |
| Popis: | Pulmonary arterial hypertension (PAH) is a complex pulmonary vascular disease that leads to right ventricular (RV) failure and sudden cardiac death (1). PAH is associated with sympathetic nervous system (SNS) over-stimulation, renin-angiotensin-aldosterone system (RAAS) activation and cardiac arrhythmias. RAAS activation generates vasoactive compounds that result in pulmonary vasoconstriction and vascular remodeling, hallmarks of PAH (2). It is suggested that patients with PAH often have a low cardiac output and that RAAS and SNS over-activation are merely compensatory mechanisms for that decreased cardiac output (3). |
| Databáze: | OpenAIRE |
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