The Prognostic Value, in Active Ulcerative Colitis, of An Increased Intensity of Colonic Perivisceral Fat Signal on Magnetic Resonance Imaging With Ferumoxil
| Autor: | Giuseppe Scaglione, Gabriele Mazzacca, G. Vicinanza, F. P. D'armiento, Raffaele Bennato, Giuseppe Belfiore, Agesilao D'Arienzo, Francesco Manguso |
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| Přispěvatelé: | D'Arienzo, A, Scaglione, G, Bennato, R, Manguso, F, Vicinanza, G, Belfiore, G, D'Armiento, FRANCESCO PAOLO, Mazzacca, G. |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pancolitis Time Factors Siloxanes Colon Iron medicine.medical_treatment Contrast Media Risk Assessment Group B ulcerative coliti Recurrence medicine Humans Clinical significance Magnetite Nanoparticles Colectomy Hepatology medicine.diagnostic_test business.industry Gastroenterology Oxides Magnetic resonance imaging Histology Prognosis medicine.disease Magnetic Resonance Imaging Ulcerative colitis Ferrosoferric Oxide Intensity (physics) ferumoxil Adipose Tissue Case-Control Studies Colitis Ulcerative Female medicine.symptom Nuclear medicine business prognosi Follow-Up Studies |
| Zdroj: | American Journal of Gastroenterology. 96:481-486 |
| ISSN: | 0002-9270 |
| Popis: | OBJECTIVE: In active ulcerative colitis (UC), magnetic resonance imaging (MRI) with ferumoxil, a superparamagnetic oral contrast agent, accurately evaluates, in our experience, the increased wall thickness and frequently shows a stronger perivisceral fat signal intensity (PFSI). The aim of our study was to evaluate the clinical significance of these MRI findings in active UC. METHODS: Twenty-four consecutive patients affected by moderate pancolitis were enrolled. At entry, each patient underwent MRI with ferumoxil to evaluate wall thickness and PFSI. Two groups of patients were individuated: group A (increased PFSI) and group B (normal PFSI). After obtaining remission, the number of relapses and, at each flare-up, the clinical activity index (CAI) were evaluated in all patients in a 2-yr follow-up period. The mean CAI was calculated at the end of the follow-up in each patient. Where there was colectomy, a complete histological examination of the colon was performed. RESULTS: PFSI was increased in 16 patients (group A) and was normal in the remainder (group B). There was a significant difference of wall thickness, number of relapses/yr, and mean CAI between the two groups of patients. No difference was observed with regard the duration of disease. Six patients of group A and no patient of group B underwent colectomy. The histological evaluation showed an increased thickness of the entire colonic wall with significant changes of the perivisceral fat structures. CONCLUSIONS: An increased PFSI on MRI identifies a group of UC patients with an increased wall thickness, significantly higher than that observed in patients with normal PFSI and seems to be related to a poor prognosis. |
| Databáze: | OpenAIRE |
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