Intensified large artery and microvascular response to cold adrenergic stimulation in African blacks
| Autor: | Christophe Janssen, Oliver Lheureux, William Ngatchou, Jean-François Argacha, Jean-Paul Degaute, Dionysios Adamopoulos, Sofia Beloka, Philippe van de Borne, Daniel Lemogoum, Patricia Kayembe |
|---|---|
| Přispěvatelé: | Clinical sciences, Cardio-vascular diseases, Cardiology |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Mean arterial pressure medicine.medical_specialty European Continental Ancestry Group Black People Blood Pressure White People Africa/ethnology Heart Rate Internal medicine Heart rate Internal Medicine medicine Laser-Doppler Flowmetry Humans Carotid Arteries/physiology Pulse Blood Pressure/physiology Pulse wave velocity African Continental Ancestry Group Skin business.industry Vascular Resistance/drug effects Cold pressor test medicine.disease Skin/blood supply Elasticity Cold Temperature Femoral Artery Blood pressure Endocrinology Carotid Arteries Regional Blood Flow Vasoconstriction Femoral Artery/physiology Africa Arterial stiffness Vascular Resistance medicine.symptom Cardiology and Cardiovascular Medicine business Heart Rate/physiology Negroid |
| Zdroj: | American journal of hypertension. 22(9) |
| ISSN: | 1941-7225 |
| Popis: | BACKGROUND: Arterial stiffening is more accelerated in blacks than in whites. Whether this is attributed to an enhanced vascular reactivity to environmental stress stimulation remains unknown. We therefore decided to test the hypothesis that cold pressor test (CPT) elicits a greater increase in arterial stiffness and an enhanced sympathetic skin vasoconstriction in African blacks than in whites normotensives. METHODS: A total of 17 young normotensive African blacks and 17 normotensive whites were recruited. All underwent continuous assessment of blood pressure (BP), heart rate, and carotid-femoral pulse wave velocity (PWVc-f) at rest, during and after hand immersion in iced water (CPT). Concomitantly, skin microvascular blood flow was monitored by laser Doppler flowmetry on the opposite hand. RESULTS: At baseline, African blacks exhibited higher values of PWVc-f than whites (7.2 +/- 0.3 vs. 6.5 +/- 0.2 m/s, respectively, P = 0.04). During CPT the increases in systolic BP and PWVc-f were greater in African blacks than in whites (systolic BP 17 +/- 2 mm Hg vs. 9 +/- 3 mm Hg, P < 0.001 and PWVc-f 0.62 +/- 0.1 m/s vs. 0.26 +/- 0.1 m/s, P = 0.03, respectively). However, there was no significant difference in the PWVc-f responses among the groups during CPT after adjustment for the increments in mean BP. Finally, CPT induced a more pronounced skin microvascular vasoconstriction in African blacks than in whites (-54.4 +/- 5 % vs. -31.3 +/- 6 %, P < 0.001). CONCLUSIONS: CPT provokes a more pronounced increase in PWVc-f in normotensive African blacks than in whites, that appears to be due to a greater increase in mean BP. Additionally, African blacks present an intensified skin microvascular response to the CPT as compared to their whites counterparts. |
| Databáze: | OpenAIRE |
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